Side-effects of l-dopa on venous tone in Parkinson's disease : a leg-weighing assessment
Identifieur interne : 002A92 ( Main/Exploration ); précédent : 002A91; suivant : 002A93Side-effects of l-dopa on venous tone in Parkinson's disease : a leg-weighing assessment
Auteurs : Jean-Pierre Wolf [France] ; Malika Bouhaddi [France] ; Francis Louisy [France] ; Andrei Mikehiev [France] ; Laurent Mourot [France] ; Sylvie Cappelle [France] ; Fabrice Vuillier [France] ; Pierre Andre [France] ; Lucien Rumbach [France] ; Jacques Regnard [France]Source :
- Clinical science : (1979) [ 0143-5221 ] ; 2006.
Descripteurs français
- Pascal (Inist)
- Wicri :
- topic : Médecine.
English descriptors
- KwdEn :
- Adult, Aged, Antianginal agent, Antiparkinson Agents (adverse effects), Antiparkinson agent, Blood Pressure (drug effects), Blood vessel, Body weight, Cardiac Output (drug effects), Check, Coronary vasodilator agent, Corporal biometry, Dopamine Agents, Epinephrine (blood), Female, Heart Rate (drug effects), Humans, Intravenous administration, Leg, Leg (blood supply), Leg (pathology), Levodopa, Levodopa (adverse effects), Male, Medicine, Middle Aged, Nitroglycerin, Norepinephrine, Norepinephrine (blood), Organ Size (drug effects), Parkinson Disease (blood), Parkinson Disease (drug therapy), Parkinson Disease (physiopathology), Parkinson disease, Plethysmography, Posture, Regulation(control), Reproducibility of Results, Secondary effect, Tilt-Table Test, Toxicity, Vein.
- MESH :
- chemical , adverse effects : Antiparkinson Agents, Levodopa.
- chemical , blood : Epinephrine, Norepinephrine.
- blood : Parkinson Disease.
- blood supply : Leg.
- drug effects : Blood Pressure, Cardiac Output, Heart Rate, Organ Size.
- drug therapy : Parkinson Disease.
- pathology : Leg.
- physiopathology : Parkinson Disease.
- Adult, Aged, Dopamine Agents, Female, Humans, Male, Middle Aged, Plethysmography, Posture, Reproducibility of Results, Tilt-Table Test.
Abstract
In the present study, the effects of L-dopa treatment on cardiovascular variables and peripheral venous tone were assessed in 13 patients with Parkinson's disease (PD) with Hoehn and Yahr stages 1-4. Patients were investigated once with their regular treatment and once after 12 h of interruption of L-dopa treatment. L-Dopa intake significantly reduced systolic and diastolic blood pressure, heart rate and plasma noradrenaline and adrenaline in both the supine and upright (60°) positions. A significant reduction in stroke volume and cardiac output was also seen with L-dopa. The vascular status of the legs was assessed through thigh compression during leg weighing, a new technique developed in our laboratory. Healthy subjects were used to demonstrate that this technique provided reproducible results, consistent with those provided by strain gauge plethysmography of the calf. When using this technique in patients with PD, L-dopa caused a significant lowering of vascular tone in the lower limbs as shown, in particular, by an increase in venous distensibility. Combined with the results of the orthostatic tilting, these findings support that the treatment-linked lowering of plasma noradrenaline in patients with PD was concomitant with a significant reduction in blood pressure, heart rate and vascular tone in the lower limbs. These pharmacological side-effects contributed to reduce venous return and arterial blood pressure which, together with a lowered heart rate, worsened the haemodynamic status.
Url:
Affiliations:
- France
- Bourgogne-Franche-Comté, Franche-Comté, Île-de-France
- Besançon, Bretigy sur Orge
- Université de Franche-Comté
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Le document en format XML
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de Franche Comté</s1><s2>25030 Besançon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName><orgName type="university">Université de Franche-Comté</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Explorations Fonctionnelles-Physiologie, Centre Hospitalier Universitaire</s1><s2>25030 Besançon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Bouhaddi, Malika" sort="Bouhaddi, Malika" uniqKey="Bouhaddi M" first="Malika" last="Bouhaddi">Malika Bouhaddi</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Physiologie, Faculte de Médecine and UPRES EA 3920 - IFR 133, Universite de Franche Comté</s1><s2>25030 Besançon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName><orgName type="university">Université de Franche-Comté</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Explorations Fonctionnelles-Physiologie, Centre Hospitalier Universitaire</s1><s2>25030 Besançon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" 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aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName><orgName type="university">Université de Franche-Comté</orgName></affiliation></author><author><name sortKey="Mourot, Laurent" sort="Mourot, Laurent" uniqKey="Mourot L" first="Laurent" last="Mourot">Laurent Mourot</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Physiologie, Faculte de Médecine and UPRES EA 3920 - IFR 133, Universite de Franche Comté</s1><s2>25030 Besançon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName><orgName type="university">Université de 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nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author><author><name sortKey="Vuillier, Fabrice" sort="Vuillier, Fabrice" uniqKey="Vuillier F" first="Fabrice" last="Vuillier">Fabrice Vuillier</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Neurologie, Centre Hospitalier Universitaire and UPRES EA 3920 - IFR 133</s1><s2>Besançon, 25030</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region></placeName></affiliation></author><author><name sortKey="Andre, Pierre" sort="Andre, Pierre" uniqKey="Andre P" first="Pierre" last="Andre">Pierre Andre</name><affiliation wicri:level="4"><inist:fA14 i1="04"><s1>Ecole Nationale Supérieure de Mécanique et des Microtechniques (ENSMM), Universite de Franche-Comté</s1><s2>25030 Besançon</s2><s3>FRA</s3><sZ>4 aut.</sZ><sZ>8 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName><orgName type="university">Université de Franche-Comté</orgName></affiliation></author><author><name sortKey="Rumbach, Lucien" sort="Rumbach, Lucien" uniqKey="Rumbach L" first="Lucien" last="Rumbach">Lucien Rumbach</name><affiliation wicri:level="3"><inist:fA14 i1="05"><s1>Neurologie, Centre Hospitalier Universitaire and UPRES EA 3920 - IFR 133</s1><s2>Besançon, 25030</s2><s3>FRA</s3><sZ>7 aut.</sZ><sZ>9 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region></placeName></affiliation></author><author><name sortKey="Regnard, Jacques" sort="Regnard, Jacques" uniqKey="Regnard J" first="Jacques" last="Regnard">Jacques Regnard</name><affiliation wicri:level="4"><inist:fA14 i1="01"><s1>Physiologie, Faculte de Médecine and UPRES EA 3920 - IFR 133, Universite de Franche Comté</s1><s2>25030 Besançon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName><orgName type="university">Université de Franche-Comté</orgName></affiliation><affiliation wicri:level="3"><inist:fA14 i1="02"><s1>Explorations Fonctionnelles-Physiologie, Centre Hospitalier Universitaire</s1><s2>25030 Besançon</s2><s3>FRA</s3><sZ>1 aut.</sZ><sZ>2 aut.</sZ><sZ>5 aut.</sZ><sZ>6 aut.</sZ><sZ>10 aut.</sZ></inist:fA14><country>France</country><placeName><region type="region" nuts="2">Bourgogne-Franche-Comté</region><region type="old region" nuts="2">Franche-Comté</region><settlement type="city">Besançon</settlement></placeName></affiliation></author></analytic><series><title level="j" type="main">Clinical science : (1979)</title><title level="j" type="abbreviated">Clin. sci. : (1979)</title><idno type="ISSN">0143-5221</idno><imprint><date when="2006">2006</date></imprint></series></biblStruct></sourceDesc><seriesStmt><title level="j" type="main">Clinical science : (1979)</title><title level="j" type="abbreviated">Clin. sci. : (1979)</title><idno type="ISSN">0143-5221</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>Adult</term><term>Aged</term><term>Antianginal agent</term><term>Antiparkinson Agents (adverse effects)</term><term>Antiparkinson agent</term><term>Blood Pressure (drug effects)</term><term>Blood vessel</term><term>Body weight</term><term>Cardiac Output (drug effects)</term><term>Check</term><term>Coronary vasodilator agent</term><term>Corporal biometry</term><term>Dopamine Agents</term><term>Epinephrine (blood)</term><term>Female</term><term>Heart Rate (drug effects)</term><term>Humans</term><term>Intravenous administration</term><term>Leg</term><term>Leg (blood supply)</term><term>Leg (pathology)</term><term>Levodopa</term><term>Levodopa (adverse effects)</term><term>Male</term><term>Medicine</term><term>Middle Aged</term><term>Nitroglycerin</term><term>Norepinephrine</term><term>Norepinephrine (blood)</term><term>Organ Size (drug effects)</term><term>Parkinson Disease (blood)</term><term>Parkinson Disease (drug therapy)</term><term>Parkinson Disease (physiopathology)</term><term>Parkinson disease</term><term>Plethysmography</term><term>Posture</term><term>Regulation(control)</term><term>Reproducibility of Results</term><term>Secondary effect</term><term>Tilt-Table Test</term><term>Toxicity</term><term>Vein</term></keywords><keywords scheme="MESH" type="chemical" qualifier="adverse effects" xml:lang="en"><term>Antiparkinson Agents</term><term>Levodopa</term></keywords><keywords scheme="MESH" type="chemical" qualifier="blood" xml:lang="en"><term>Epinephrine</term><term>Norepinephrine</term></keywords><keywords scheme="MESH" qualifier="blood" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="blood supply" xml:lang="en"><term>Leg</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Blood Pressure</term><term>Cardiac Output</term><term>Heart Rate</term><term>Organ Size</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" qualifier="pathology" xml:lang="en"><term>Leg</term></keywords><keywords scheme="MESH" qualifier="physiopathology" xml:lang="en"><term>Parkinson Disease</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Adult</term><term>Aged</term><term>Dopamine Agents</term><term>Female</term><term>Humans</term><term>Male</term><term>Middle Aged</term><term>Plethysmography</term><term>Posture</term><term>Reproducibility of Results</term><term>Tilt-Table Test</term></keywords><keywords scheme="Pascal" xml:lang="fr"><term>Parkinson maladie</term><term>Effet secondaire</term><term>Toxicité</term><term>Lévodopa</term><term>Veine</term><term>Voie intraveineuse</term><term>Jambe</term><term>Biométrie corporelle</term><term>Poids corporel</term><term>Nitroglycérine</term><term>Noradrénaline</term><term>Régulation</term><term>Contrôle</term><term>Vaisseau sanguin</term><term>Pléthysmographie</term><term>Médecine</term><term>Antiparkinsonien</term><term>Antiangoreux</term><term>Vasodilatateur coronarien</term></keywords><keywords scheme="Wicri" type="topic" xml:lang="fr"><term>Médecine</term></keywords></textClass></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">In the present study, the effects of L-dopa treatment on cardiovascular variables and peripheral venous tone were assessed in 13 patients with Parkinson's disease (PD) with Hoehn and Yahr stages 1-4. Patients were investigated once with their regular treatment and once after 12 h of interruption of L-dopa treatment. L-Dopa intake significantly reduced systolic and diastolic blood pressure, heart rate and plasma noradrenaline and adrenaline in both the supine and upright (60°) positions. A significant reduction in stroke volume and cardiac output was also seen with L-dopa. The vascular status of the legs was assessed through thigh compression during leg weighing, a new technique developed in our laboratory. Healthy subjects were used to demonstrate that this technique provided reproducible results, consistent with those provided by strain gauge plethysmography of the calf. When using this technique in patients with PD, L-dopa caused a significant lowering of vascular tone in the lower limbs as shown, in particular, by an increase in venous distensibility. Combined with the results of the orthostatic tilting, these findings support that the treatment-linked lowering of plasma noradrenaline in patients with PD was concomitant with a significant reduction in blood pressure, heart rate and vascular tone in the lower limbs. These pharmacological side-effects contributed to reduce venous return and arterial blood pressure which, together with a lowered heart rate, worsened the haemodynamic status.</div></front></TEI><affiliations><list><country><li>France</li></country><region><li>Bourgogne-Franche-Comté</li><li>Franche-Comté</li><li>Île-de-France</li></region><settlement><li>Besançon</li><li>Bretigy sur Orge</li></settlement><orgName><li>Université de Franche-Comté</li></orgName></list><tree><country name="France"><region name="Bourgogne-Franche-Comté"><name sortKey="Wolf, Jean Pierre" sort="Wolf, Jean Pierre" uniqKey="Wolf J" first="Jean-Pierre" last="Wolf">Jean-Pierre Wolf</name></region><name sortKey="Andre, Pierre" sort="Andre, Pierre" uniqKey="Andre P" first="Pierre" last="Andre">Pierre Andre</name><name sortKey="Bouhaddi, Malika" sort="Bouhaddi, Malika" uniqKey="Bouhaddi M" first="Malika" last="Bouhaddi">Malika Bouhaddi</name><name sortKey="Bouhaddi, Malika" sort="Bouhaddi, Malika" uniqKey="Bouhaddi M" first="Malika" last="Bouhaddi">Malika Bouhaddi</name><name sortKey="Cappelle, Sylvie" sort="Cappelle, Sylvie" uniqKey="Cappelle S" first="Sylvie" last="Cappelle">Sylvie Cappelle</name><name sortKey="Louisy, Francis" sort="Louisy, Francis" uniqKey="Louisy F" first="Francis" last="Louisy">Francis Louisy</name><name sortKey="Mikehiev, Andrei" sort="Mikehiev, Andrei" uniqKey="Mikehiev A" first="Andrei" last="Mikehiev">Andrei Mikehiev</name><name sortKey="Mourot, Laurent" sort="Mourot, Laurent" uniqKey="Mourot L" first="Laurent" last="Mourot">Laurent Mourot</name><name sortKey="Mourot, Laurent" sort="Mourot, Laurent" uniqKey="Mourot L" first="Laurent" last="Mourot">Laurent Mourot</name><name sortKey="Regnard, Jacques" sort="Regnard, Jacques" uniqKey="Regnard J" first="Jacques" last="Regnard">Jacques Regnard</name><name sortKey="Regnard, Jacques" sort="Regnard, Jacques" uniqKey="Regnard J" first="Jacques" last="Regnard">Jacques Regnard</name><name sortKey="Rumbach, Lucien" sort="Rumbach, Lucien" uniqKey="Rumbach L" first="Lucien" last="Rumbach">Lucien Rumbach</name><name sortKey="Vuillier, Fabrice" sort="Vuillier, Fabrice" uniqKey="Vuillier F" first="Fabrice" last="Vuillier">Fabrice Vuillier</name><name sortKey="Wolf, Jean Pierre" sort="Wolf, Jean Pierre" uniqKey="Wolf J" first="Jean-Pierre" last="Wolf">Jean-Pierre Wolf</name></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
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